Sharmila Majumdar, PhD
UCSF Professor and Vice Chair of Research
Department of Radiology and Biomedical Imaging
Relating the rate of 18FNaF uptake in the medial tibia and the cartilage T1ρ at each voxel we find correlations between bone remodeling and cartilage proteoglycan changes not just in the adjoining region, but in several different parts of the knee joint. Showing a connectivity between cartilage and bone changes in OA that goes beyond just adjoining regions.
Below you can see that the higher the bone remodeling, or 18F-NaF uptake, the:
-Higher the T1ρ or the loss of proteoglycan in the medial tibia (adjoining region)
-Higher the T1ρ or the loss of proteoglycan in the patella (non-adjoining compartment or bone)
-Lower the T1ρ or the loss of proteoglycan in the trochlea (non-adjoining compartment or bone)